20241203

 
结构=(信息)⇒功能
 
分化是基因差异表达的结果
THE CELL 第七章 gene control
早期认为细胞分化是DNA不断丢失,所以才有体细胞克隆实验,去证明体细胞中仍然有全部的基因组信息。
生物学 都是条件性的必然性。
Epigenetic landscaping: how chromatin is regulated to achieve proper gene expression during cell differentiation?
 
Gene regulation
  • transcriptional control
  • RNA-processing control
  • RNA transport & localization control
  • mRNA degradation control
  • translational control
  • protein degradation control